Many scientists all over the world are interested in the benefits of royal jelly. As we can see from the medical report, it confirms that the use of royal jelly can cure some illnesses, for example:
- Dr. Destrem (1956), gave 134 elderly (aged between 70 and 75), anorexic, depressed and patients with low-blood pressured royal jelly. After taking it only 6 times, these patients became stronger. It has been claimed that 20 mg injected every second day helped improve on all accounts and 20 mg taken orally every second day helped improve general condition, increase weight, appetite, RBC and hemoglobin.
- Dr.Sarrouy and his team (1956), fed royal jelly to children who severely lacked of nutrition. It was found that they gained weight and looked much healthier, with twinkling eyes and rosy cheek.
- Dr. Chauvin (1957), reported the experiment of feeding royal jelly to neurotics, low blood pressured and exhausted subjects. It showed that after taking a limit amount of royal jelly, the patients recovered noticeably from the ailments. They were able to eat better, their blood pressure turned into normal, and neurotic symptoms disappeared.
- Dr. Borgia et al (1984), studied chronic metabolism with a mixture of royal jelly, honey and ginseng. He concluded that royal jelly yielded improvements in weight gain and psychological conditions along with changes to blood characteristics
Fresh Royal Jelly supplies many minerals, including calcium, copper, iron,
phosphorus, potassium, silicon, and sulfur, as well as the eight amino acids
essential to human life.
All the above mentioned, vitamins and minerals have the following health benefits:
Primary Applications of Pure Fresh Royal Jelly
More information about benefits of women health and royal jelly here.
How can you increase you chance to get pregnant with Fresh Royal Jelly from Royal Health farm Ireland.
Other benefits of royal jelly.
Royal Jelly Uses and Pharmacology
Recent clinical trials are lacking and suggested pharmacologic effects are largely based on in vitro and animal model experiments.
The protein royalisin found in royal jelly has potent in vitro antibacterial activity against gram-positive bacteria, but not against gram-negative bacteria. Hydroxydecanoic acid has in vitro bacteriostatic activity against Streptococcus aureus and Escherichia coli . These antibacterial components are believed to modestly enhance host defenses in honeybees. Additive or synergistic effects have been demonstrated in vitro with starch and honey. 14 , 15 , 16
Antioxidant activity has been demonstrated with royal jelly using different in vitro and plant models, 17 , 18 , 19 , 20 while protection against oxidative stress-induced injury has been demonstrated in animal experiments. 18 , 21 , 22 , 23 Lipid peroxidation was inhibited in vitro and in experiments in rats; however, clinical data are lacking. 24
Royal jelly exhibited antitumor activity in experimental mouse leukemias, 25 and antiangiogenesis activity has also been demonstrated in vitro. 8 In human cervico/uterine carcinoma cells, some royal jelly fractions actively inhibited tumor growth and some did not. 10 One study found that royal jelly inhibited the growth-promoting effect of bisphenol on breast cancer MCF-7 cell lines, although another study showed that royal jelly enhanced MCF-7 proliferation. 13 , 26
A number of studies evaluated royal jelly for relief of menopausal symptoms in the 1970s. However, recent clinical trials are lacking. Binding to estrogenic receptors (weak in comparison with diethstilbesterol and phytoestrogens), stimulation of mRNA expression in estrogen-responsive genes, and enhanced MCF-7 cell proliferation (which could be blocked by tamoxifen) have all been demonstrated in vitro. 13 , 27 Animal experiments in rats and ewes have also been conducted. Mild hypertrophy of the uterine luminal epithelium was achieved in rats supplemented with royal jelly, 13 while effects in ewes were varied. The effect of royal jelly supplementation on the onset of estrus has shown mixed results in ewes, with one trial showing no effect, while another exhibiting a shorter time to estrus compared with control and no difference compared with gonadotropin. 28 , 29 , 30 In both experiments, positive effects on pregnancy and lambing rates were demonstrated.
In tissue culture models and ovariectomized rats, a positive effect on osteoporosis was demonstrated. Increased calcium content and recovered bone mass were suggested to be the results of enhanced intestinal calcium absorption, rather than antagonism of the parathyroid hormone. 31
As a result of GI enzymatic hydrolysis, peptides derived from royal jelly demonstrated angiotensin 1–converting enzyme inhibitory activity in the spontaneously hypertensive rat. Other studies suggest trans-2-octenoic acid and hydroxydecanoic acid may account for the antihypertensive activity, but different fractions exert lesser or greater effects on duration of action. Royal jelly also was associated with a protective action and therapeutic activity in adrenaline-induced arrhythmia; however, no effect on heart rate has been observed. 32 , 33 , 34 , 35
Various in vitro experiments have examined the actions of royal jelly and its constituents on the immune system. 4 , 36 , 37 , 38 , 39 , 40 Experiments in animals have demonstrated immunoregulatory activities, with the administration of royal jelly (500 to 1,500 mg/kg body weight/day) increasing survival in tumor-bearing mice and demonstrating positive effects on bone marrow stem cells and tumor-induced splenic hematopoiesis. 41 Additionally, auto-immunity was inhibited in systemic lupus erythematous-prone mice, with a delay in disease progression, decreased proteinuria, and increased survival. 42 Increased healing rates were observed in guinea pig tympanic membrane perforation. 43
In an in vitro study using lymphocytes from healthy volunteers and patients with Graves disease, royal jelly caused lymphocytes to proliferate and certain cytokines to be secreted, suggesting a potential immunomodulatory role in the management of this disease. 44
In rats and in vitro experiments, insulin-like activity has been shown with royal jelly, and components may be structurally and functionally related to insulin. In an insulin-resistance model in rats, royal jelly reduced plasma insulin and triglycerides without affecting plasma glucose levels. 10 , 35
Small clinical trials have demonstrated mixed effects on the lipid profile in humans. Royal jelly administered at 10 g/day for 14 days increased serum high-density lipid (HDL) levels in elderly participants, while a trend toward improved low-density lipid (LDL) levels was seen with no effect on serum triglycerides. 45 In another trial, 6 g/day for 4 weeks resulted in decreased serum total cholesterol and LDL, but had no effect on HDL or triglycerides. 46
Traditional use of royal jelly in preventing aging has led to experiments regarding neuronal activities. Stimulation of production of glial cell line-derived neurotrophic factor has been demonstrated in the adult mouse brain, with a prediction of a neuroprotective role for royal jelly. 47 In addition, 10-hydroxy-trans-2-decanoic acid increased the generation of neurons from neural stem (progenitor) cells in vitro, 48 while adenosine monophosphate stimulated neuronal differentiation of pheochromocytoma PC12 cells. 49
Activity on the pituitary gland in middle-aged rats has also been demonstrated, 50 and orally administered royal jelly increased granule cell content in the hippocampus, with an observed improvement in induced cognitive impairment in mice. 48
Clinical trials are generally lacking to recommend dosage. Small clinical trials have used 6 to 10 g/day for 14 to 28 days in trials evaluating the effect on hyperlipidemia. 45 , 46
Information regarding safety and efficacy in pregnancy and lactation is lacking. Estrogenic effects of royal jelly and its constituents have been demonstrated in animals. 13 , 27 , 28 , 29 , 30 , 31
Case reports of hematuria due to potentiation of warfarin have been documented. 51 Based on a few animal experiments, a theoretical potentiation of the activity of insulin exists. 10 , 35
In many allergy patients, skin tests were positive for royal jelly. There have been reports of allergy, acute exacerbation of asthma, anaphylaxis, and death. 51 , 52 , 53 , 54 , 55 , 56
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